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T1D AUTOANTIBODY SCREENING

PROACTIVE SCREENING FOR AUTOANTIBODIES CAN IDENTIFY IF AN IMMUNE ATTACK IS HAPPENING1

A zoomed out cluster of animated beta cells with worried expressions
SCREENING CAN SIGNAL RISK

When islet T1D autoantibodies are present, it means beta cells are in danger.1

Further zoomed out clusters of animated beta cells with worried expressions
THE ADA RECOMMENDS PROACTIVELY SCREENING AT-RISK PATIENTS FOR THE FOLLOWING 4 ISLET AAbs2*

 GADA
(glutamic acid decarboxylase 65 AAb)

IA-2A
(insulinoma-associated antigen 2 AAb)

IAA
(insulin AAb)

ZnT8A
(zinc transporter-8 AAb)

*Islet cell AAb (ICA) is also available for testing.3

AAb=autoantibody; T1D=type 1 diabetes.

If AAbs are present, an underlying autoimmune attack is underway, and beta cells are at risk.1

References

  1. Scheiner G, Weiner S, Kruger D, Pettus J. Screening for type 1 diabetes: Role of the diabetes care and education specialist. ADCES Pract. 2022;10(5):20-25.  
  2. American Diabetes Association Professional Practice Committee. Diagnosis and classification of diabetes: standards of care in diabetes—2025. Diabetes Care. 2025;48(Suppl 1):S27-S49.
  3. Phillip M, Achenbach P, Addala A, et al. Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes. Diabetes Care. 2024;47(8):1276-1298. 

MAT-US-2504446-v1.0-05/2025